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Molecular oracles for multiple sclerosis therapy

Nature Medicine volume 16, pages 376–377 (2010)Cite this article

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Fewer than half of patients with multiple sclerosis respond to interferon-b, one of the most widely prescribed therapies. The discovery that different subtypes of T cells may be involved in disease development in each affected individual suggests that it may be possible to predict therapeutic success by determining a patient's cytokine profile (pages 406–412).

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Figure 1: Differential effects of IFN-β treatment in subgroups of human multiple sclerosis (ms) and in a mouse model, experimental autoimmune encephalomyelitis (EAE).

References

  1. Rudick, R.A. & Polman, C.H. Lancet Neurol. 8, 545–559 (2009).

    Article  Google Scholar 

  2. Axtell, R.C. et al. Nat. Med. 16, 406–412 (2010).

    Article  CAS  Google Scholar 

  3. Steinman, L. J. Exp. Med. 205, 1517–1522 (2008).

    Article  CAS  Google Scholar 

  4. Mestas, J. & Hughes, C.C.W. J. Immunol. 172, 2731–2738 (2004).

    Article  CAS  Google Scholar 

  5. Tzartos, J.S. et al. Am. J. Pathol. 172, 146–155 (2008).

    Article  CAS  Google Scholar 

  6. Durelli, L. et al. Ann. Neurol. 65, 499–509 (2009).

    Article  CAS  Google Scholar 

  7. Ramgolam, V.S., Sha, Y.G., Jin, J.P., Zhang, X. & Markovic-Plese, S. J. Immunol. 183, 5418–5427 (2009).

    Article  CAS  Google Scholar 

  8. Byrnes, A.A., McArthur, J.C. & Karp, C.L. Ann. Neurol. 51, 165–174 (2002).

    Article  CAS  Google Scholar 

  9. Wandinger, K.P. et al. Lancet 361, 2036–2043 (2003).

    Article  CAS  Google Scholar 

  10. Comabella, M. et al. Brain 132, 3353–3365 (2009).

    Article  CAS  Google Scholar 

  11. Baranzini, S.E. et al. PLoS Biol. 3, e2 (2005).

    Article  Google Scholar 

  12. Bielekova, B. & Martin, R. Brain 127, 1463–1478 (2004).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Hartmut Wekerle and Reinhard Hohlfeld are at the Max Planck Institute of Neurobiology, Martinsried and Institute of Clinical Neuroimmunology, Ludwig-Maximilians University, Munich, Germany.,

    Hartmut Wekerle & Reinhard Hohlfeld

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  1. Hartmut Wekerle
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  2. Reinhard Hohlfeld
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Competing interests

Part of H.W.’s research have been supported by Novartis and Morphosys. He has received speaker’s honoraria from multiple companies. R.H. received consultancy fees or grant support from pharmaceutical companies marketing or developing treatments for multiple sclerosis, including Bayer, Teva, Sanofi, Biogen-Idec, Merck-Serono and Novartis.

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Wekerle, H., Hohlfeld, R. Molecular oracles for multiple sclerosis therapy. Nat Med 16, 376–377 (2010). https://doi.org/10.1038/nm0410-376

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