Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Taming TLR4 may ease seizures

Nature Medicine volume 16, pages 369–370 (2010)Cite this article

Subjects

Activation of Toll-like receptors (TLRs) via a nuclear protein released from dying cells, high-mobility group box-1 (HMGB1) protein, leads to chronic epilepsy in rat models and in human epileptic tissue. Blocking this inflammatory pathway may constitute a new antiepileptic treatment strategy (pages 413–419).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Interaction between HMGB1 and TLR4 promotes seizures.

Kim Caesar

References

  1. Kwan, P. & Brodie, M.J. N. Engl. J. Med. 342, 314–319 (2000).

    Article  CAS  Google Scholar 

  2. Rogawski, M.A. & Loscher, W. Nat. Rev. Neurosci. 5, 553–564 (2004).

    Article  CAS  Google Scholar 

  3. Maroso, M. et al. Nat. Med. 16, 413–419 (2010).

    Article  CAS  Google Scholar 

  4. Sayyah, M. et al. Neuroscience 122, 1073–1080 (2003).

    Article  CAS  Google Scholar 

  5. Galic, M.A. et al. J. Neurosci. 28, 6904–6913 (2008).

    Article  CAS  Google Scholar 

  6. De Simoni, M.G. et al. Eur. J. Neurosci. 12, 2623–2633 (2000).

    Article  CAS  Google Scholar 

  7. Vezzani, A. et al. Proc. Natl. Acad. Sci. USA 97, 11534–11539 (2000).

    Article  CAS  Google Scholar 

  8. Fabene, P.F. et al. Nat. Med. 14, 1377–1383 (2008).

    Article  CAS  Google Scholar 

  9. Balosso, S. et al. Brain 131, 3256–3265 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jonathan K. Kleen and Gregory L. Holmes are in the Department of Neurology at Dartmouth Medical School, Hanover, New Hampshire, USA.,

    Jonathan K Kleen & Gregory L Holmes

Authors
  1. Jonathan K Kleen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gregory L Holmes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gregory L Holmes.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kleen, J., Holmes, G. Taming TLR4 may ease seizures. Nat Med 16, 369–370 (2010). https://doi.org/10.1038/nm0410-369

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0410-369

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research