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Neutrophil sandwiches injure the microcirculation

Experiments in two mouse models of thromboinflammatory disease show how neutrophils stick to red blood cells and platelets—leading to reduced blood flow and damage to the microcirculation. Polarized expression of αMβ2 integrins on neutrophils helps set the process in motion (pages 384–391).

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Figure 1: Heterotypic interactions of neutrophils in the inflamed microvasculature.

Kim Caesar

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Looney, M., Matthay, M. Neutrophil sandwiches injure the microcirculation. Nat Med 15, 364–366 (2009). https://doi.org/10.1038/nm0409-364

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