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T effectors outfox T regulators in autoimmunity

Nature Medicine volume 13, pages 411–413 (2007)Cite this article

Findings from a mouse model of multiple sclerosis suggest that regulatory T cells alone cannot outduel pathogenic T cells in the central nervous system. The observations may have implications for experimental approaches designed to dampen autoimmune diseases by infusion of regulatory T cells (pages 423–431).

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Figure 1: T-reg fail to control CNS T-eff at the peak of EAE.

Kim Caesar

References

  1. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol. 155, 1151–1164 (1995).

    CAS  PubMed  Google Scholar 

  2. Tang, Q. et al. J. Exp. Med. 199, 1455–1465 (2004).

    Article  CAS  Google Scholar 

  3. Viglietta, V., Baecher-Allan, C., Weiner, H.L. & Hafler, D.A. J. Exp. Med. 199, 971–979 (2004).

    Article  CAS  Google Scholar 

  4. 4. Korn, T et al. Nat. Med. 13, 423–431 (2007).

  5. Hori, S., Nomura, T. & Sakaguchi, S. Science 299, 1057–1061 (2003).

    Article  CAS  Google Scholar 

  6. Walker, L.S., Chodos, A., Eggena, M., Dooms, H. & Abbas, A.K. J. Exp. Med. 198, 249–258 (2003).

    Article  CAS  Google Scholar 

  7. Bettelli, E. et al. Nature 441, 235–238 (2006).

    Article  CAS  Google Scholar 

  8. Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. Immunity 24, 179–189 (2006).

    Article  CAS  Google Scholar 

  9. McGeachy, M.J., Stephens, L.A. & Anderton, S.M. J. Immunol. 175, 3025–3032 (2005).

    Article  CAS  Google Scholar 

  10. Zhang, X. et al. Int. Immunol. 16, 249–256 (2004).

    Article  CAS  Google Scholar 

  11. Chitnis, T. et al. J. Clin. Invest. 108, 739–747 (2001).

    Article  CAS  Google Scholar 

  12. Tang, Q. & Bluestone, J.A. Immunol. Rev. 212, 217–237 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology and Program in Immunology, University of California San Francisco, San Francisco, 94143, California, USA

    Thomas Prod'homme, Martin S Weber & Scott S Zamvil

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  1. Thomas Prod'homme
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  2. Martin S Weber
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  3. Scott S Zamvil
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Prod'homme, T., Weber, M. & Zamvil, S. T effectors outfox T regulators in autoimmunity. Nat Med 13, 411–413 (2007). https://doi.org/10.1038/nm0407-411

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