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Providing AID to p53 mutagenesis

Activation-induced cytidine deaminase (AID), which mediates antibody diversification, is now implicated as an inducer of p53 mutagenesis in cancer cells (pages 470–476).

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Figure 1: Aberrant AID expression triggered by H. pylori–infection causes frequent p53 mutations in gastric epithelial cells.

Kim Caesar

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Takaishi, S., Wang, T. Providing AID to p53 mutagenesis. Nat Med 13, 404–406 (2007). https://doi.org/10.1038/nm0407-404

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