Intracellular oxidants may contribute to overall lifespan, in part by affecting stem cells. The connection between oxidants and aging now gains strength in a study of hematopoietic stem cells, which respond to oxidants by activating a pathway leading to stem cell exhaustion (pages 446–451).
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References
Harman, D. J. Gerontol. 11, 298–300 (1956).
Balaban, R.S., Nemoto, S. & Finkel, T. Cell 120, 483–495 (2005).
Ito, K et al. Nat. Med. 12, 446–451 (2006).
Ito, K. et al. Nature 431, 997–1002 (2004).
Rotman, G. & Shiloh, Y. Bioessays 19, 911–917 (1997).
Schubert, R. et al. Hum. Mol. Genet. 13, 1793–1802 (2004).
Cheng, T. et al. Science 287, 1804–1808 (2000).
Tonks, N.K. Cell 121, 667–670 (2005).
Sundaresan, M., Yu, Z.X., Ferrans, V.J., Irani, K. & Finkel, T. Science 270, 296–9 (1995).
Park, I.K. et al. Nature 423, 302–305 (2003).
Voncken, J.W. et al. J. Biol. Chem. 280, 5178–5187 (2005).
Pagano, G. et al. Eur. J. Haematol. 75, 93–100 (2005).
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Liu, J., Finkel, T. Stem cell aging: what bleach can teach. Nat Med 12, 383–384 (2006). https://doi.org/10.1038/nm0406-383
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DOI: https://doi.org/10.1038/nm0406-383
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