Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cell aging: what bleach can teach

Nature Medicine volume 12, pages 383–384 (2006)Cite this article

Intracellular oxidants may contribute to overall lifespan, in part by affecting stem cells. The connection between oxidants and aging now gains strength in a study of hematopoietic stem cells, which respond to oxidants by activating a pathway leading to stem cell exhaustion (pages 446–451).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Reactive oxygen species modulate stem cell proliferation.

Katie Ris

References

  1. Harman, D. J. Gerontol. 11, 298–300 (1956).

    Article  CAS  Google Scholar 

  2. Balaban, R.S., Nemoto, S. & Finkel, T. Cell 120, 483–495 (2005).

    Article  CAS  Google Scholar 

  3. Ito, K et al. Nat. Med. 12, 446–451 (2006).

    Article  CAS  Google Scholar 

  4. Ito, K. et al. Nature 431, 997–1002 (2004).

    Article  CAS  Google Scholar 

  5. Rotman, G. & Shiloh, Y. Bioessays 19, 911–917 (1997).

    Article  CAS  Google Scholar 

  6. Schubert, R. et al. Hum. Mol. Genet. 13, 1793–1802 (2004).

    Article  CAS  Google Scholar 

  7. Cheng, T. et al. Science 287, 1804–1808 (2000).

    Article  CAS  Google Scholar 

  8. Tonks, N.K. Cell 121, 667–670 (2005).

    Article  CAS  Google Scholar 

  9. Sundaresan, M., Yu, Z.X., Ferrans, V.J., Irani, K. & Finkel, T. Science 270, 296–9 (1995).

    Article  CAS  Google Scholar 

  10. Park, I.K. et al. Nature 423, 302–305 (2003).

    Article  CAS  Google Scholar 

  11. Voncken, J.W. et al. J. Biol. Chem. 280, 5178–5187 (2005).

    Article  CAS  Google Scholar 

  12. Pagano, G. et al. Eur. J. Haematol. 75, 93–100 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, 20892, Maryland, USA

    Jie Liu & Toren Finkel

Authors
  1. Jie Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toren Finkel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, J., Finkel, T. Stem cell aging: what bleach can teach. Nat Med 12, 383–384 (2006). https://doi.org/10.1038/nm0406-383

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0406-383

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing