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Getting to the guts of NOD2

Mutations in NOD2, encoding an intracellular bacteria-sensing protein, have been associated recently with Crohn disease. Two studies in mice investigate how these mutations may affect innate immunity to microbes in the intestine and progression of disease.

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Figure 1: Models of activation and regulaton of NOD and TLR pathways by peptidoglycan.

Katherine Ris

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Kelsall, B. Getting to the guts of NOD2. Nat Med 11, 383–384 (2005). https://doi.org/10.1038/nm0405-383

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