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Pain killer without a high

THC acts as a pain reliever in part by engaging a receptor in peripheral tissues, CB2. But exactly where CB2 is and how it operates has been unclear. A new study shows that cannabinoids, acting through CB2 on skin cells, stimulate the local release of endogenous opioids.

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Figure 1: CB2 and pain.

Katherine Ris


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Monory, K., Lutz, B. Pain killer without a high. Nat Med 11, 378–379 (2005).

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