Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

MET orchestrates cancer and blood coagulation

Nature Medicine volume 11, pages 376–377 (2005)Cite this article

A new mouse model begins to unravel a longstanding mystery: why are cancers often associated with blood coagulation disorders?

The close interconnection between cancer and thrombosis, often referred to as Trousseau syndrome, was first appreciated almost one and a half centuries ago1, and has been widely documented in the basic and clinical literature. Indeed, markers of a perturbed coagulation system are often used as diagnostic and prognostic indicators of malignancy. Insights into the mechanisms underlying this connection have been stymied by the absence of an animal model in which a hemostatic disorder is tightly linked to malignancy.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Connecting coagulation and cancer.

Ann Thomson

References

  1. Trousseau, A. Clinique Médicale de l'Hôtel-Dieu de Paris 3, 654–712 (1865). (J.B. Balliere et Fils, Paris, 1865).

    Google Scholar 

  2. Boccaccio, C. et al. Nature 434, 396–400 (2005).

    Article  CAS  Google Scholar 

  3. Blom, J.W., Doggen, C.J.M., Osanto, S. & Rosendaal, F.R. JAMA 293, 715–722 (2005).

    Article  CAS  Google Scholar 

  4. Linehan, W.M., Walther, M.M. & Zbar, B. J. Urol. 170, 2163–2172 (2003).

    Article  CAS  Google Scholar 

  5. Jafri, N.F., Ma, P.C., Maulik, G. & Salgia, R. J. Environ. Pathol. Toxicol. Oncol. 22, 147–165 (2003).

    Article  CAS  Google Scholar 

  6. Knudsen, B.S. & Edlund, M. Adv. Cancer Res. 91, 31–67 (2004).

    Article  CAS  Google Scholar 

  7. von Tempelhoff, G.F., Pollow, K., Schneider, D. & Heilmann, L. Clin. Appl. Thromb. Hemost. 5, 92–104 (1999).

    Article  CAS  Google Scholar 

  8. Schmitt, M., Kuhn, W., Harbeck, N. & Graeff, H. Semin. Thromb. Hemost. 25, 157–166 (1999).

    Article  CAS  Google Scholar 

  9. Levine, M.N., Lee, A.Y. & Kakkar, A.K. J. Thromb. Haemost. 1, 1456-1463 (2003).

  10. VanDeWater, L., Tracy, P.B., Aronson, D., Mann, K.G. & Dvorak, H.F. Cancer Res. 45, 5521–5525 (1985).

    CAS  Google Scholar 

  11. Versteeg, H.H., Spek, C.A., Peppelenbosch, M.P. & Richel, D.J. Mol. Med. 10, 6–11 (2004).

    Article  CAS  Google Scholar 

  12. Im, J.H. et al. Cancer Res. 64, 8613–8619 (2004).

    Article  CAS  Google Scholar 

  13. Gasic, G.J., Gasic, T.B. & Stewart, C.C. Proc. Natl. Acad. Sci. USA 61, 46–52 (1968).

    Article  CAS  Google Scholar 

  14. Prins, M.H., Hettiarachchi, R.J., Lensing, A.W. & Hirsh, J. Thromb. Haemost. 78, 121–125 (1997).

    Article  CAS  Google Scholar 

  15. Agnelli, G. Thromb. Haemost. 78, 117–120 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Cardiology, the Cleveland Clinic Foundation, Cleveland, 44195, Ohio, USA

    Olga I Stenina & Edward F Plow

Authors
  1. Olga I Stenina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Edward F Plow
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Stenina, O., Plow, E. MET orchestrates cancer and blood coagulation. Nat Med 11, 376–377 (2005). https://doi.org/10.1038/nm0405-376

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0405-376

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing