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Setting a trap for tissue fibrosis

The accumulation of fibroblasts in epithelial organs such as the kidney can produce dangerous scars. Such tissue fibrosis begins when epithelial cells morph into fibroblasts by epithelial-mesenchymal transition. A key regulator of this process in the kidney now emerges (pages 387–393).

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Figure 1: Overview of a epithelial-mesenchymal transition controlled by TGF-β and BMP7.

Katherine Ris


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Neilson, E. Setting a trap for tissue fibrosis. Nat Med 11, 373–374 (2005).

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