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Setting a trap for tissue fibrosis

Nature Medicine volume 11, pages 373–374 (2005)Cite this article

The accumulation of fibroblasts in epithelial organs such as the kidney can produce dangerous scars. Such tissue fibrosis begins when epithelial cells morph into fibroblasts by epithelial-mesenchymal transition. A key regulator of this process in the kidney now emerges (pages 387–393).

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Figure 1: Overview of a epithelial-mesenchymal transition controlled by TGF-β and BMP7.

Katherine Ris

References

  1. Iwano, M. et al. J. Clin. Invest. 110, 341–350 (2002).

    Article  CAS  Google Scholar 

  2. Kalluri, R. & Neilson, E.G. J. Clin. Invest. 112, 1776–1784 (2003).

    Article  CAS  Google Scholar 

  3. Lin, J. et al. Nat. Med. 11, 387–393 (2005).

    Article  CAS  Google Scholar 

  4. Shi, Y. & Massague, J. Cell 113, 685–700 (2003).

    Article  CAS  Google Scholar 

  5. Sato, M., Muragaki, Y., Saika, S., Roberts, A.B. & Ooshima, A. J. Clin. Invest. 112, 1486–1494 (2003).

    Article  CAS  Google Scholar 

  6. Kim, K., Lu, Z. & Hay, E.D. Cell. Biol. Int. 26, 463–476 (2002).

    Article  CAS  Google Scholar 

  7. Zeisberg, M. et al. Nat. Med. 9, 964–968 (2003).

    Article  CAS  Google Scholar 

  8. Zeisberg, M. & Kalluri, R. J. Mol. Med. 82, 175–181 (2004).

    Article  Google Scholar 

  9. Wang, S. et al. Kidney Int. 63, 2037–2049 (2003).

    Article  CAS  Google Scholar 

  10. Morrissey, J. et al. J. Am. Soc. Nephrol. 13 (Suppl. 1), S14–S21 (2002).

    CAS  PubMed  Google Scholar 

  11. Balemans, W. & Van Hul, W. Dev. Biol. 250, 231–250 (2002).

    Article  CAS  Google Scholar 

  12. Border, W.A. et al. Nature 360, 361–364 (1992).

    Article  CAS  Google Scholar 

  13. Abreu, J.G., Ketpura, N.I., Reversade, B. & De Robertis, E.M. Nat. Cell. Biol. 4, 599–604 (2002).

    Article  CAS  Google Scholar 

  14. Garcia Abreu, J., Coffinier, C., Larrain, J., Oelgeschlager, M. & De Robertis, E.M. Gene 287, 39–47 (2002).

    Article  CAS  Google Scholar 

  15. Bullard, K.M., Longaker, M.T. & Lorenz, H.P. World J. Surg. 27, 54–61 (2003).

    Article  Google Scholar 

Download references

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  1. Departments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, 37232, Tennessee, USA

    Eric G Neilson

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  1. Eric G Neilson
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Neilson, E. Setting a trap for tissue fibrosis. Nat Med 11, 373–374 (2005). https://doi.org/10.1038/nm0405-373

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