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The vicious cyclin of addiction

Drug addiction is a major therapeutic challenge, as little is known about the changes in neural function that occur during its development. DNA microarray analysis has revealed a new component in the dopamine-receptor–signaling cascade that may contribute to the neural and behavioral plasticity associated with addiction.

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Figure 1: Acute and chronic effects of cocaine on the dopamine receptor (D1) signaling pathway.

Bob Crimi

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White, F., Cooper, D. The vicious cyclin of addiction. Nat Med 7, 416–417 (2001). https://doi.org/10.1038/86480

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