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COX-2 as a multifunctional neuronal modulator

COX-2 is involved in prostaglandin synthesis and expressed throughout the nervous system, where it participates in pain sensitivity and in synaptic plasticity. Microsomal prostaglandin E synthase, expressed throughout the nervous system microvasculature, may be another important player in neural aspects of the inflammatory response.

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Figure 1: Regulatory checkpoints of peripheral pain hypersensitivity and of systemic inflammation.


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Bazan, N. COX-2 as a multifunctional neuronal modulator. Nat Med 7, 414–415 (2001).

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