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COX-2 as a multifunctional neuronal modulator

Nature Medicine volume 7, pages 414–415 (2001)Cite this article

COX-2 is involved in prostaglandin synthesis and expressed throughout the nervous system, where it participates in pain sensitivity and in synaptic plasticity. Microsomal prostaglandin E synthase, expressed throughout the nervous system microvasculature, may be another important player in neural aspects of the inflammatory response.

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Figure 1: Regulatory checkpoints of peripheral pain hypersensitivity and of systemic inflammation.

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  1. Neuroscience Center and Department of Ophthalmology School of Medicine Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

    Nicolas G. Bazan

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  1. Nicolas G. Bazan
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Bazan, N. COX-2 as a multifunctional neuronal modulator. Nat Med 7, 414–415 (2001). https://doi.org/10.1038/86477

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