Abstract
Too much or too little NMDA receptor activity during development can result in neuronal cell death. Recent work suggests that NMDA receptor blockade can cause excessive neuronal apoptosis in the perinatal brain.
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References
Shakespeare, W. Hamlet II.ii.
Bliss, T.V.P. & Collingridge, G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361 , 31–39 (1993).
Balazs, R., Hack, N. & Jorgensen, O.S. Interactive effects involving different classes of excitatory amino acid receptors and the survival of cerebellar granule cells in culture. Int. J. Dev. Neurosci. 8, 347 –359 (1990).
Pearce, I.A., Cambray, D.M. & Burgoyne, R.D. Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells. FEBS Lett. 223, 143–147 (1987).
Komuro, H. & Rakic, P. Modulation of neuronal migration by NMDA receptors. Science 260, 95– 97 (1993).
Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P. & Lipton, S.A. Apoptosis and necrosis: two distinct events induced respectively by mild and intense insults with NMDA or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92, 7162–7166 ( 1995).
Ikonomidou, C. et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283, 70 –74 (1999).
Lipton, S.A. & Kater, S.B. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci. 12, 265–270 (1989).
Lipton, S.A. & Rosenberg, P.A. Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613–622 (1994).
Li, Y., Erzurumlu, R.S., Chen, C., Jhaveri, S. & Tonegawa, S. Whisker-related neuronal patterns fails to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76, 427–437 (1994).
Sucher, N.J. et al. Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J. Neurosci . 15, 6509–6520 ( 1995).
Ciabarra, A.M. et al. Cloning and characterization of χ-1: A developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J. Neurosci. 15, 6498– 6508 (1995).
Das, S. et al. Increased NMDA current and spine density in mice lacking the NMDAR subunit, NR3A. Nature 377–381 (1998).
Nakanishi, S. Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597–603 (1992).
Kutsuwada, T. et al. Molecular diversity of the NMDA receptor channel. Nature 358, 36–41 ( 1992).
Monyer, H. et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217– 1221 (1992).
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Lipton, S., Nakanishi, N. Shakespeare in love—with NMDA receptors?. Nat Med 5, 270–271 (1999). https://doi.org/10.1038/6481
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DOI: https://doi.org/10.1038/6481
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