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Impaired wound healing in mice with a disrupted plasminogen gene

Nature Medicine volume 2, pages 287–292 (1996)Cite this article

Abstract

Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in Plg by targeted gene disruption. The results demonstrate that Plg is required for normal repair of skin wounds in mice and support the assumption that it also plays a central role in other disease processes involving extracellular matrix degradation, such as cancer invasion.

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Authors and Affiliations

  1. The Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, DK-2100, Copenhagen Ø, Denmark

    John Rømer, Thomas H. Bugge, Charles Fyke & Keld Danø

  2. Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, Ohio, 45229, USA

    Thomas H. Bugge, Matthew J. Flick & Jay L. Degen

  3. Laboratory of Radiobiology and Environmental Health, University of California, San Francisco, California, 94143-0750, USA

    Leif R. Lund

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  1. John Rømer
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  6. Jay L. Degen
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  7. Keld Danø
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Rømer, J., Bugge, T., Fyke, C. et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med 2, 287–292 (1996). https://doi.org/10.1038/nm0396-287

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