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A close look at cancer

Nature Medicine volume 17, pages 262–265 (2011)Cite this article

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Advances in cancer research are enabling fast-paced discovery and translation of results into potential clinical tools. Here we consider some of the most influential findings of the past two years, selected by experts in the cancer field.

In 2010, we asked more than 400 experts to help us identify papers published within the previous two years that have made a significant impact on the field of cancer. By doing so we hoped to highlight those papers influencing current thinking and funding trends, pinpoint key questions stimulating the cancer field and help identify gaps in the knowledge and focus of cancer research. One hundred and fifty respondents recommended 319 papers (compiled in the tables on p 280), and the most frequently selected papers are discussed in greater depth in News & Views and Research Highlights in the ensuing pages.

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Figure 1: Notable advances in cancer research.

References

  1. Quintana, E. et al. Nature 456, 593–598 (2008).

    Google Scholar 

  2. Parsons, D.W. et al. Science 321, 1807–1812 (2008).

    Google Scholar 

  3. Cancer Genome Atlas Research Network. Nature 455, 1061–1068 (2008).

  4. Jones, S. et al. Science 321, 1801–1806 (2008).

    Google Scholar 

  5. Mardis, E.R. et al. N. Engl. J. Med. 361, 1058–1066 (2009).

    Google Scholar 

  6. Mossé, Y.P. et al. Nature 455, 930–935 (2008).

    Google Scholar 

  7. Wood, L.D. et al. Science 318, 1108–1113 (2007).

    Google Scholar 

  8. Pleasance, E.D. et al. Nature 463, 184–190 (2010).

    Google Scholar 

  9. Mullighan, C.G. et al. Science 322, 1377–1380 (2008).

    Google Scholar 

  10. Yan, H. et al. N. Engl. J. Med. 360, 765–773 (2009).

    Google Scholar 

  11. Dang, L. et al. Nature 462, 739–744 (2009).

    Google Scholar 

  12. Ward, P.S. et al. Cancer Cell 17, 225–234 (2010).

    Google Scholar 

  13. Lapidot, T. et al. Nature 367, 645–648 (1994).

    Google Scholar 

  14. Kelly, P.N. et al. Science 317, 337 (2007).

    Google Scholar 

  15. Mani, S.A. et al. Cell 133, 704–715 (2008).

    Google Scholar 

  16. Rosen, J.M. & Jordan, C.T. Science 324, 1670–1673 (2009).

    Google Scholar 

  17. Al-Hajj, M. et al. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).

    Google Scholar 

  18. Barker, N. et al. Nature 457, 608–611 (2009).

    Google Scholar 

  19. Goldstein, A.S. et al. Science 329, 568–571 (2010).

    Google Scholar 

  20. Poulikakos, P.I. et al. Nature 464, 427–430 (2010).

    Google Scholar 

  21. Hatzivassiliou, G. et al. Nature 464, 431–435 (2010).

    Google Scholar 

  22. Heidorn, S.J. et al. Cell 140, 209–221 (2010).

    Google Scholar 

  23. Edwards, S.L. et al. Nature 451, 1111–1115 (2008).

    Google Scholar 

  24. Sakai, W. et al. Nature 451, 1116–1120 (2008).

    Google Scholar 

  25. Fong, P.C. et al. N. Engl. J. Med. 361, 123–134 (2009).

    Google Scholar 

  26. Sharma, S.V. et al. Cell 141, 69–80 (2010).

    Google Scholar 

  27. Weber, J.S. et al. J. Clin. Oncol. 26, 5950–5956 (2008).

    Google Scholar 

  28. DeNardo, D.G. et al. Cancer Cell 16, 91–102 (2009).

    Google Scholar 

  29. Andreu, P. et al. Cancer Cell 17, 121–134 (2010).

    Google Scholar 

Download references

Acknowledgements

We thank all of our survey respondents for their seminal insights into the recent advances in cancer research and the authors of the Book Reviews, News & Views, Timeline, Perspectives and Reviews for their crucial contributions to this Focus on Cancer.

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  1. Alison Farrell is a senior editor of Nature Medicine.,

    Alison Farrell

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  1. Alison Farrell
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Farrell, A. A close look at cancer. Nat Med 17, 262–265 (2011). https://doi.org/10.1038/nm0311-262

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