Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

# A close look at cancer

### Subjects

Advances in cancer research are enabling fast-paced discovery and translation of results into potential clinical tools. Here we consider some of the most influential findings of the past two years, selected by experts in the cancer field.

## Relevant articles

• ### TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

BMC Cancer Open Access 06 September 2012

## Access options

\$32.00

All prices are NET prices.

## References

1. Quintana, E. et al. Nature 456, 593–598 (2008).

2. Parsons, D.W. et al. Science 321, 1807–1812 (2008).

3. Cancer Genome Atlas Research Network. Nature 455, 1061–1068 (2008).

4. Jones, S. et al. Science 321, 1801–1806 (2008).

5. Mardis, E.R. et al. N. Engl. J. Med. 361, 1058–1066 (2009).

6. Mossé, Y.P. et al. Nature 455, 930–935 (2008).

7. Wood, L.D. et al. Science 318, 1108–1113 (2007).

8. Pleasance, E.D. et al. Nature 463, 184–190 (2010).

9. Mullighan, C.G. et al. Science 322, 1377–1380 (2008).

10. Yan, H. et al. N. Engl. J. Med. 360, 765–773 (2009).

11. Dang, L. et al. Nature 462, 739–744 (2009).

12. Ward, P.S. et al. Cancer Cell 17, 225–234 (2010).

13. Lapidot, T. et al. Nature 367, 645–648 (1994).

14. Kelly, P.N. et al. Science 317, 337 (2007).

15. Mani, S.A. et al. Cell 133, 704–715 (2008).

16. Rosen, J.M. & Jordan, C.T. Science 324, 1670–1673 (2009).

17. Al-Hajj, M. et al. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).

18. Barker, N. et al. Nature 457, 608–611 (2009).

19. Goldstein, A.S. et al. Science 329, 568–571 (2010).

20. Poulikakos, P.I. et al. Nature 464, 427–430 (2010).

21. Hatzivassiliou, G. et al. Nature 464, 431–435 (2010).

22. Heidorn, S.J. et al. Cell 140, 209–221 (2010).

23. Edwards, S.L. et al. Nature 451, 1111–1115 (2008).

24. Sakai, W. et al. Nature 451, 1116–1120 (2008).

25. Fong, P.C. et al. N. Engl. J. Med. 361, 123–134 (2009).

26. Sharma, S.V. et al. Cell 141, 69–80 (2010).

27. Weber, J.S. et al. J. Clin. Oncol. 26, 5950–5956 (2008).

28. DeNardo, D.G. et al. Cancer Cell 16, 91–102 (2009).

29. Andreu, P. et al. Cancer Cell 17, 121–134 (2010).

## Acknowledgements

We thank all of our survey respondents for their seminal insights into the recent advances in cancer research and the authors of the Book Reviews, News & Views, Timeline, Perspectives and Reviews for their crucial contributions to this Focus on Cancer.

Authors

## Ethics declarations

### Competing interests

The author declares no competing financial interests.

## Rights and permissions

Reprints and Permissions

Farrell, A. A close look at cancer. Nat Med 17, 262–265 (2011). https://doi.org/10.1038/nm0311-262

• Published:

• Issue Date:

• DOI: https://doi.org/10.1038/nm0311-262

• ### TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

• Lionel Flamant
• Edith Roegiers
• Carine Michiels

BMC Cancer (2012)

• ### Somatic variation and cancer: therapies lost in the mix

• Andrew V. Biankin
• Thomas J. Hudson

Human Genetics (2011)