Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The other sweet face of XBP-1

X-box–binding protein-1 (XBP-1) increases insulin sensitivity by activating endoplasmic reticulum capacity during feeding to control glucose homeostasis, a function severely impaired in obesity. But XBP-1 can also increase glucose tolerance in obese and diabetic mice by blocking gluconeogenesis, independent of its effect on insulin sensitivity, opening new avenues for type 2 diabetes therapies (pages 356–365).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: A dual mechanistic role for XBP-1 in improving glucose homeostasis.

Katie Vicari


  1. Schröder, M. & Kaufman, R.J. Annu. Rev. Biochem. 74, 739–789 (2005).

    Article  Google Scholar 

  2. Hotamisligil, G.S. Cell 140, 900–917 (2010).

    Article  CAS  Google Scholar 

  3. Sriburi, R. et al. J. Cell Biol. 167, 35–41 (2004).

    Article  CAS  Google Scholar 

  4. Zhou, Y. et al. Nat. Med. 17, 356–365 (2011).

    Article  CAS  Google Scholar 

  5. Gross, D.N. et al. Oncogene 27, 2320–2336 (2008).

    Article  CAS  Google Scholar 

  6. Ozcan, U. et al. Science 306, 457–461 (2004).

    Article  Google Scholar 

  7. Park, S.W. et al. Nat. Med. 16, 429–437 (2010).

    Article  CAS  Google Scholar 

  8. Winnay, J.N. et al. Nat. Med. 16, 438–445 (2010).

    Article  CAS  Google Scholar 

  9. Ozcan, U. et al. Science 313, 1137–1140 (2006).

    Article  Google Scholar 

  10. Ozcan, L. et al. Cell Metab. 9, 35–51 (2009).

    Article  CAS  Google Scholar 

  11. Kitamura, T. et al. Nat. Med. 12, 534–540 (2006).

    Article  CAS  Google Scholar 

  12. Marciniak, S.J. & Ron, D. Physiol. Rev. 86, 1133–1149 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kohjiro Ueki.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ueki, K., Kadowaki, T. The other sweet face of XBP-1. Nat Med 17, 246–248 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing