Between Bedside and Bench | Published:

Asthma and allergy: The emerging epithelium

Nature Medicine volume 16, pages 273274 (2010) | Download Citation

Thinking about how asthma and allergic diseases arise is undergoing several shifts. In 'Bedside to Bench', Clare M. Lloyd and Sejal Saglani examine how recent human studies are putting the focus on the epithelium as a major contributor to asthma. The findings shift the emphasis away from the T helper type 2 immune response, and call into question the utility of current animal models of the disease. Although asthma and other allergic disorders are known to have origins in infancy, some researchers are looking even earlier, to effects in utero and before conception. In 'Bench to Bedside', Catherine Hawrylowicz and Kimuli Ryanna highlight animal studies that outline some of the effects of the maternal environment, and they examine the potential implications for prevention of disease.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Am. J. Respir. Crit. Care Med. 180, 929–935 (2009).

  2. 2.

    et al. N. Engl. J. Med. 360, 985–993 (2009).

  3. 3.

    et al. N. Engl. J. Med. 360, 973–984 (2009).

  4. 4.

    et al. Am. J. Respir. Crit. Care Med. 181, 315–323 (2010).

  5. 5.

    , & Curr. Allergy Asthma Rep. 9, 3–9 (2009).

  6. 6.

    et al. Nature 448, 470–473 (2007).

  7. 7.

    & Nat. Rev. Immunol. 8, 193–204 (2008).

  8. 8.

    et al. Nat. Med. 15, 410–416 (2009).

  9. 9.

    et al. Proc. Natl. Acad. Sci. USA 104, 15858–15863 (2007).

  10. 10.

    et al. Am. J. Respir. Crit. Care Med. 180, 388–395 (2009).

  11. 11.

    & Am. J. Respir. Crit. Care Med. 180, 383–384 (2009).

Download references

Author information

Affiliations

  1. Clare M. Lloyd and Sejal Saglani are at the Leukocyte Biology Section, UK Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, National Heart and Lung Institute, Imperial College, London, UK.

    • Clare M Lloyd
    •  & Sejal Saglani

Authors

  1. Search for Clare M Lloyd in:

  2. Search for Sejal Saglani in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Clare M Lloyd.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm0310-273

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing