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The knockout rat pack

The rat is the preferred model organism in many fields of biomedicine, such as toxicology testing. But when it comes to disease models, rats have been upstaged by mice, which traditionally were far easier to genetically engineer. Elie Dolgin follows the tale of the researchers who are bringing the rat back into the race.

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  1. Zan, Y. et al. Nat. Biotech. 21, 645–651 (2003).

    Article  CAS  Google Scholar 

  2. Amos-Landgraf, J.M. et al. Proc. Natl. Acad. Sci. USA 104, 4036–4041 (2007).

    Article  CAS  Google Scholar 

  3. Geurts, A.M. et al. Science 325, 433 (2009).

    Article  CAS  Google Scholar 

  4. Buehr, M. et al., Cell 135, 1287–1298 (2008).

    Article  CAS  Google Scholar 

  5. Li, P. et al. Cell 135, 1299–1310 (2008).

    Article  CAS  Google Scholar 

  6. Liao, J. et al. Cell Stem Cell 4, 11–15 (2009).

    Article  CAS  Google Scholar 

  7. Liu, H. et al. Cell Stem Cell 4, 16–19 (2009).

    Article  Google Scholar 

  8. Ivics, Z. et al. Cell 91, 501–510 (1997).

    Article  CAS  Google Scholar 

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Dolgin, E. The knockout rat pack. Nat Med 16, 254–257 (2010).

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