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Getting a handle on Huntington's disease: the case for cholesterol

Nature Medicine volume 15, pages 253–254 (2009)Cite this article

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Since the first description in 1872 (ref. 1) of Huntington's disease—a hereditary neurodegenerative disease characterized by progressive movement disorder, cognitive decline and psychiatric disturbances—tremendous efforts have been made to cure it. However, no effective therapy exists, except for a few symptomatic treatments, such as tetrabenezine, which attenuates involuntary movement.

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Figure 1: Disrupted cholesterol metabolism may contribute to neurodegeneration in Huntington's disease.

Katie Vicari

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Authors and Affiliations

  1. Hiroaki Adachi and Gen Sobue are in the Department of Neurology, Masahisa Katsuno, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-ku, Nagoya 466-8550, Japan. sobueg@med.nagoya-u.ac.jp,

    Masahisa Katsuno, Hiroaki Adachi & Gen Sobue

  2. Masahisa Katsuno is also at the Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan ka2no@med.nagoya-u.ac.jp,

    Masahisa Katsuno

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  1. Masahisa Katsuno
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  2. Hiroaki Adachi
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  3. Gen Sobue
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Katsuno, M., Adachi, H. & Sobue, G. Getting a handle on Huntington's disease: the case for cholesterol. Nat Med 15, 253–254 (2009). https://doi.org/10.1038/nm0309-253

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