Oxygen sensor boosts growth factor signaling

Activation of hypoxia-inducible factor, a molecule central to oxygen sensing, can promote the survival and growth of tumor cells. New experiments dissect a pathway behind this effect—upregulation of the epidermal growth factor receptor (pages 319–324).

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Figure 1: Oxygen starvation feeds EGF.

Katie Vicari

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Hung, M., Mills, G. & Yu, D. Oxygen sensor boosts growth factor signaling. Nat Med 15, 246–247 (2009). https://doi.org/10.1038/nm0309-246

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