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NO may prompt calcium leakage in dystrophic muscle

A remote, downstream event in the pathology of muscular dystrophy may have a key role in the disease (pages 325–330). It seems that induction of nitric oxide synthase causes calcium to leak inside the cell through ryanodine receptors. The findings provide new options for therapeutic interventions.

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Figure 1: Defects in the regulation of Ca2+ entry into the cytoplasm of muscle from intracellular stores or the extracellular space contribute to the pathology of muscular dystrophy.

Katie Vicari

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Tidball, J., Villalta, S. NO may prompt calcium leakage in dystrophic muscle. Nat Med 15, 243–244 (2009). https://doi.org/10.1038/nm0309-243

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  • DOI: https://doi.org/10.1038/nm0309-243

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