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NO may prompt calcium leakage in dystrophic muscle

A remote, downstream event in the pathology of muscular dystrophy may have a key role in the disease (pages 325–330). It seems that induction of nitric oxide synthase causes calcium to leak inside the cell through ryanodine receptors. The findings provide new options for therapeutic interventions.

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Figure 1: Defects in the regulation of Ca2+ entry into the cytoplasm of muscle from intracellular stores or the extracellular space contribute to the pathology of muscular dystrophy.

Katie Vicari


  1. Petrof, B.J. et al. Proc. Natl. Acad. Sci. USA 90, 3710–3714 (1993).

    Article  CAS  Google Scholar 

  2. Bellinger, A.M. et al. Nat. Med. 15, 325–330 (2009).

    Article  CAS  Google Scholar 

  3. Ganster, R.W. et al. Proc. Natl. Acad. Sci. USA 98, 8638–8643 (2001).

    Article  CAS  Google Scholar 

  4. Wehling, M. et al. J. Cell Biol. 155, 123–131 (2001).

    Article  CAS  Google Scholar 

  5. Radley, H.G. et al. Neuromusc. Disord. 18, 227–238 (2008).

    Article  Google Scholar 

  6. Messina, S. et al. Exp. Neurol. 198, 234–241 (2006).

    Article  CAS  Google Scholar 

  7. Villalta, S.A. et al. Hum. Mol. Genet. 18, 482–496 (2009).

    Article  CAS  Google Scholar 

  8. Stahn, C. & Buttgereit, F. Nat. Clin. Pract. Rheumatol. 4, 525–533 (2008).

    Article  CAS  Google Scholar 

  9. Mokri, B. & Engel, A.G. Neurology 25, 1111–1120 (1975).

    Article  CAS  Google Scholar 

  10. Turner, P.R. et al. J. Cell Biol. 115, 1701–1712 (1991).

    Article  CAS  Google Scholar 

  11. Yeung, E.W. et al. J. Physiol. (Lond.) 562, 367–380 (2005).

    Article  CAS  Google Scholar 

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Tidball, J., Villalta, S. NO may prompt calcium leakage in dystrophic muscle. Nat Med 15, 243–244 (2009).

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