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NO may prompt calcium leakage in dystrophic muscle

Nature Medicine volume 15, pages 243–244 (2009)Cite this article

A remote, downstream event in the pathology of muscular dystrophy may have a key role in the disease (pages 325–330). It seems that induction of nitric oxide synthase causes calcium to leak inside the cell through ryanodine receptors. The findings provide new options for therapeutic interventions.

The most common form of muscular dystrophy, Duchenne muscular dystrophy (DMD), is relentlessly progressive, invariably fatal and strangely complex.

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Figure 1: Defects in the regulation of Ca2+ entry into the cytoplasm of muscle from intracellular stores or the extracellular space contribute to the pathology of muscular dystrophy.

Katie Vicari

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Authors and Affiliations

  1. James G. Tidball and S. Armando Villalta are in the Molecular, Cellular & Integrative Physiology Program, University of California, 621 Charles E. Young Drive South, Los Angeles, California 90095-1606, USA. jtidball@physci.ucla.edu,

    James G Tidball & S Armando Villalta

  2. James G. Tidball is also in the Department of Physiological Science, University of California and the Department of Pathology and Laboratory Medicine at the David Geffen School of Medicine, University of California, 621 Charles E. Young Drive South, Los Angeles, California, 90095-1606 USA.,

    James G Tidball

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  1. James G Tidball
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  2. S Armando Villalta
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Tidball, J., Villalta, S. NO may prompt calcium leakage in dystrophic muscle. Nat Med 15, 243–244 (2009). https://doi.org/10.1038/nm0309-243

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