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Interleukin-22: a sheep in wolf's clothing

Nature Medicine volume 14, pages 247–249 (2008)Cite this article

Interleukin-22, a component of the immune system most studied for its role in autoimmunity, has a more beneficial side. Two studies show how this cytokine fights off microbes in the mucosa of the lung and gut (pages 275–281 and 282–289).

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Figure 1: IL-22 protects against extracellular bacterial pulmonary and enteric infections.

Katie Ris-Vicari

References

  1. Zheng, Y. et al. Nat. Med. 14, 275–281 (2008).

    Article  Google Scholar 

  2. Aujla, S.J. et al. Nat. Med. 14, 282–289 (2008).

    Article  Google Scholar 

  3. Weaver, C.T., Hatton, R.D., Mangan, P.R. & Harrington, L.E. Annu. Rev. Immunol. 25, 821–852 (2007).

    Article  CAS  Google Scholar 

  4. McGeachy, M.J. et al. Nat. Immunol. 8, 1390–1397 (2007).

    Article  CAS  Google Scholar 

  5. Kullberg, M.C. et al. J. Exp. Med. 203, 2485–2494 (2006).

    Article  CAS  Google Scholar 

  6. Mangan, P.R. et al. Nature 441, 231–234 (2006).

    Article  CAS  Google Scholar 

  7. Zenewicz, L.A. et al. Immunity 27, 647–659 (2007).

    Article  CAS  Google Scholar 

  8. Sugimoto, K. et al. J. Clin. Invest. 118, 534–544 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Zheng, Y. et al. Nature 445, 648–651 (2007).

    Article  CAS  Google Scholar 

  10. Ma, H.L. et al. J. Clin. Invest. 118, 597–607 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. O'Shea, J.J., Ma, A. & Lipsky, P. Nat. Rev. Immunol. 2, 37–45 (2002).

    Article  CAS  Google Scholar 

  12. Langowski, J.L. et al. Nature 442, 461–465 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Arian Laurence, John J. O'Shea and Wendy T. Watford are in the Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA. osheajo@mail.nih.gov,

    Arian Laurence, John J O'Shea & Wendy T Watford

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  1. Arian Laurence
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  2. John J O'Shea
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  3. Wendy T Watford
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Laurence, A., O'Shea, J. & Watford, W. Interleukin-22: a sheep in wolf's clothing. Nat Med 14, 247–249 (2008). https://doi.org/10.1038/nm0308-247

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