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Notch inhibition reverses kidney failure

Inhibition of the Notch pathway reverses damage in a mouse model of kidney disease (pages 290–298). The findings suggest that blockade of the Notch pathway through inhibition of γ-secretase activity may be an approach to combating glomerular failure.

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Figure 1: Notch in the kidney.

Katie Ris-Vicari

References

  1. Thiruvur, N. et al. Nat. Med. 14, 290–298 (2008).

    Article  Google Scholar 

  2. Collins, A.J. et al. Am. J. Kidney Dis. 51, S1–S320 (2008).

    PubMed  Google Scholar 

  3. Tryggvason, K., Patrakka, J. & Wartiovaara, J. N. Engl. J. Med. 354, 1387–1401 (2006).

    CAS  Article  Google Scholar 

  4. Pavenstadt, H., Kriz, W. & Kretzler, M. Physiol. Rev. 83, 253–307 (2003).

    CAS  Article  Google Scholar 

  5. Ohtaka, A. et al. Am. J. Kidney Dis. 39, 475–485 (2002).

    Article  Google Scholar 

  6. Fiuza, U.M. & Arias, A.M. J. Endocrinol. 194, 459–474 (2007).

    CAS  Article  Google Scholar 

  7. Cheng, H.T. et al. Development 130, 5031–5042 (2003).

    CAS  Article  Google Scholar 

  8. Cheng, H.T. & Kopan, R. Kidney Int. 68, 1951–1952 (2005).

    CAS  Article  Google Scholar 

  9. Nichols, J.T., Miyamoto, A. & Weinmaster, G. Traffic 8, 959–969 (2007).

    CAS  Article  Google Scholar 

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Kretzler, M., Allred, L. Notch inhibition reverses kidney failure. Nat Med 14, 246–247 (2008). https://doi.org/10.1038/nm0308-246

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  • DOI: https://doi.org/10.1038/nm0308-246

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