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Notch inhibition reverses kidney failure

Inhibition of the Notch pathway reverses damage in a mouse model of kidney disease (pages 290–298). The findings suggest that blockade of the Notch pathway through inhibition of γ-secretase activity may be an approach to combating glomerular failure.

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Figure 1: Notch in the kidney.

Katie Ris-Vicari


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Kretzler, M., Allred, L. Notch inhibition reverses kidney failure. Nat Med 14, 246–247 (2008).

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