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Notch inhibition reverses kidney failure

Nature Medicine volume 14, pages 246–247 (2008)Cite this article

Inhibition of the Notch pathway reverses damage in a mouse model of kidney disease (pages 290–298). The findings suggest that blockade of the Notch pathway through inhibition of γ-secretase activity may be an approach to combating glomerular failure.

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Figure 1: Notch in the kidney.

Katie Ris-Vicari

References

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Nephrology and Center for Computational Medicine and Biology, Matthias Kretzler and Lisa Allred are at the University of Michigan Medical Center, 1560 MSRB II, 1150 W. Medical Center Drive, Ann Arbor, Michigan 48109, USA. kretzler@umich.edu,

    Matthias Kretzler & Lisa Allred

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  1. Matthias Kretzler
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  2. Lisa Allred
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Kretzler, M., Allred, L. Notch inhibition reverses kidney failure. Nat Med 14, 246–247 (2008). https://doi.org/10.1038/nm0308-246

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