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The weakness of a big heart

A well-known cell cycle regulator, p27KIP1, and protein kinase CK2-α´ mediate pathologic growth of cardiomyocytes. The findings have potential implications for the development of new treatment approaches to cardiac hypertrophy (pages 315–324).

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Figure 1: Regulation of hypertrophic responses in the adult cardiomyocyte by p27 and CK2-α′.

Katie Ris-Vicari


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Force, T. The weakness of a big heart. Nat Med 14, 244–245 (2008).

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