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The weakness of a big heart

A well-known cell cycle regulator, p27KIP1, and protein kinase CK2-α´ mediate pathologic growth of cardiomyocytes. The findings have potential implications for the development of new treatment approaches to cardiac hypertrophy (pages 315–324).

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Figure 1: Regulation of hypertrophic responses in the adult cardiomyocyte by p27 and CK2-α′.

Katie Ris-Vicari

References

  1. Hauck, L. et al. Nat. Med. 14, 315–324 (2008).

    Article  CAS  Google Scholar 

  2. Polyak, K. et al. Genes Dev. 8, 9–22 (1994).

    Article  CAS  Google Scholar 

  3. Sherr, C.J. & Roberts, J.M. Genes Dev. 13, 1501–1512 (1999).

    Article  CAS  Google Scholar 

  4. Kaldis, P. Cell 128, 241–244 (2007).

    Article  CAS  Google Scholar 

  5. Poolman, R.A., Li, J.-M., Durand, B. & Brooks, G. Circ. Res. 85, 117–127 (1999).

    Article  CAS  Google Scholar 

  6. Li, J.-M. & Brooks, G. Am. J. Physiol. 273, H1358–H1367 (1997).

    CAS  PubMed  Google Scholar 

  7. Pasumarthi, K.B.S. & Field, L.J. Circ. Res. 90, 1044–1054 (2002).

    Article  CAS  Google Scholar 

  8. Litchfield, D.W. Biochem. J. 369, 1–15 (2003).

    Article  CAS  Google Scholar 

  9. Burton, P.B.J., Yacoub, M.H. & Barton, P.J.R. Eur. Heart J. 20, 604–611 (1999).

    Article  CAS  Google Scholar 

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Force, T. The weakness of a big heart. Nat Med 14, 244–245 (2008). https://doi.org/10.1038/nm0308-244

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