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Mycobacterial virulence and specialized secretion: same story, different ending

The genomic region lost during the attenuation of BCG vaccine encodes a newly discovered secretion system conserved among gram-positive bacteria. A series of papers has now dissected the components of this system, revealing a unique Mycobacterium tuberculosis–specific signal for export of bacterial proteins into the host.

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Figure 1: A model of the M. tuberculosis secretion system coded by the RD1 region.

Simon Fenwick


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Behr, M., Sherman, D. Mycobacterial virulence and specialized secretion: same story, different ending. Nat Med 13, 286–287 (2007).

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