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Mycobacterium tuberculosis virulence: lipids inside and out

During infections, Mycobacterium tuberculosis has to acquire nutrients and resist host defense. Lipids are important for both: host-derived lipids provide food, whereas pathogen-derived lipids mediate immune suppression.

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Figure 1: Anaplerotic reactions needed for growth with sugars or lipids and immunomodulation by phenolic glycolipids (PGL).

Simon Fenwick


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Ehrt, S., Schnappinger, D. Mycobacterium tuberculosis virulence: lipids inside and out. Nat Med 13, 284–285 (2007).

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