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Langerhans cells lap up HIV-1

Langerhans cells in the skin and mucosa have been thought to mediate the spread of HIV-1 in the body during sexual transmission. Instead, it seems that the cells protect against the virus, a finding with implications for the development of microbicides (pages 367–371).

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Figure 1: At the ready.

C Dezutter-Dambuyant/SG McCoombe & RV Short, AIDS

Figure 2: HIV-1 clearance by Langerhans cells.

Katie Ris


  1. Jolles, S. J. Clin. Pathol. 55, 243 (2002).

    Article  CAS  Google Scholar 

  2. de Witte, L. et al. Nat. Med. 13, 367–371 (2007).

    Article  CAS  Google Scholar 

  3. Kissenpfennig, A. & Malissen, B. Trends Immunol. 27, 132–139 (2006).

    Article  CAS  Google Scholar 

  4. Valladeau, J., Dezutter-Dambuyant, C. & Saeland, S. Immunol. Res. 28, 93–107 (2003).

    Article  CAS  Google Scholar 

  5. Valladeau, J. et al. Immunity 12, 71–81 (2000).

    Article  CAS  Google Scholar 

  6. Verdijk, P. et al. J. Invest. Dermatol. 124, 714–717 (2005).

    Article  CAS  Google Scholar 

  7. Turville, S.G. et al. Nat. Immunol. 3, 975–983 (2002).

    Article  CAS  Google Scholar 

  8. Kawamura, T., Kurtz, S.E., Blauvelt, A. & Shimada, S. J. Dermatol. Sci. 40, 147–155 (2005).

    Article  CAS  Google Scholar 

  9. Moris, A. et al. Blood 108, 1643–1651 (2006).

    Article  CAS  Google Scholar 

  10. Klasse, P.J., Shattock, R.J. & Moore, J.P. PLoS Med. 3, e351 (2006).

    Article  Google Scholar 

  11. Hu, J., Gardner, M.B. & Miller, C.J. J. Virol. 74, 6087–6095 (2000).

    Article  CAS  Google Scholar 

  12. Auvert, B. et al. PLoS Med. 2, e298 (2005).

    Article  Google Scholar 

  13. Hladik, F. et al. Immunity, published online 12 February 2007 (doi: 10.1016/j.immuni.2007.01.007)

    Article  CAS  Google Scholar 

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Schwartz, O. Langerhans cells lap up HIV-1. Nat Med 13, 245–246 (2007).

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