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Cracking the cytokine code in psoriasis

Psoriasis results from cross-talk between immune cells and keratinocytes in the skin. The nature of these signals now comes to light, revealing potential roles for IL-23 and a TH17 response.

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Figure 1: Cytokine networking in psoriasis—featuring the IL-23- and TH17-mediated cross-talk between activated dermal immunocytes and epidermal keratinocytes.

Ann Thomson


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Nickoloff, B. Cracking the cytokine code in psoriasis. Nat Med 13, 242–244 (2007).

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