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Stem cell mobilization by β2-agonists

Nature Medicine volume 12, pages 278–279 (2006)Cite this article

Stem cells are mobilized from the bone marrow to the peripheral blood as a source of stem cells for transplantation in cancer and genetic diseases. Exactly how the mobilization-inducing drugs operate has not been clear—but the answer may lie partly with the stimulation of bone-forming cells by signals from the sympathetic nervous system.

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Figure 1: Adrenergic innervation of endosteal osteoblasts is crucial for G-CSF–induced mobilization.

Ann Thomson

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Authors and Affiliations

  1. Division of Experimental Hematology, Cincinnati Children's Research Foundation, Cincinnati, 45229, Ohio, USA

    Jose A Cancelas & David A Williams

  2. Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, 45267, Ohio, USA

    Jose A Cancelas & David A Williams

Authors
  1. Jose A Cancelas
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  2. David A Williams
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Cancelas, J., Williams, D. Stem cell mobilization by β2-agonists. Nat Med 12, 278–279 (2006). https://doi.org/10.1038/nm0306-278

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