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Part-time cop nabs deviant DNA

Nature Medicine volume 11, pages 257–258 (2005)Cite this article

An unlikely candidate emerges as a potential new tumor suppressor: p18, a protein that helps hook tRNAs up to amino acids. p18 also mediates repair of breaks in DNA, keeping cancer at bay.

Consistent with the scope of the DNA damage response, the processes of DNA damage sensing, checkpoint signaling and DNA repair involve hundreds of different proteins, many of which have evolved specifically to fill various niches in the genome surveillance machinery. Other proteins, however, are not specialists in this arena at all, and have been co-opted from other cell-regulatory mechanisms for use in DNA damage signaling or repair. For example, many proteins involved in DNA replication or transcription maintain dual identities in various DNA damage response pathways2.

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Figure 1: Role of ARS-associated p18 in genome surveillance.

Jessica Iannuzzi

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  1. Signal Transduction Program at the Burnham Institute, La Jolla, 92130, California, USA

    Robert T Abraham

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  1. Robert T Abraham
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Abraham, R. Part-time cop nabs deviant DNA. Nat Med 11, 257–258 (2005). https://doi.org/10.1038/nm0305-257

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  • DOI: https://doi.org/10.1038/nm0305-257

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