Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Multiple sclerosis: trapped in deadly glue

Two forms of glial cells have distinct roles in the neuroinflammatory cascade of a mouse model of multiple sclerosis. These cells serve as key targets for therapeutic intervention (pages 328–334 and 335–339).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Neuroinflammation in EAE requires multiple steps of CD4+ T cell activation in distinct CNS compartments.

Deborah Maizels

References

  1. Carson, M.J., Reilly, C.R., Sutcliffe, J.G. & Lo, D. Glia 22, 72–85 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Cogle, C.R. et al. Lancet 363, 1432–1437 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. Eglitis, M.A. & Mezey, E. Proc. Natl. Acad. Sci. USA 94, 4080–4085 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jordan, F.L. & Thomas, W.E. Brain Res. 472, 165–178 (1988).

    Article  CAS  PubMed  Google Scholar 

  5. Carson, M.J. Glia 40, 218–231 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Greter, M. et al. Nat. Med. 11, 328–334 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Heppner, F.L. et al. Nat. Med. 11, 146–152 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. McMahon, E.J. et al. Nat. Med. 11, 335–339 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. Hickey, W.F. & Kimura, H. Science 239, 290–292 (1988).

    Article  CAS  PubMed  Google Scholar 

  10. Slavin A.J. J. Clin. Inv. 108, 1135–1139 (2001).

    Article  Google Scholar 

  11. Becher, B., Durell, B.G. & Noelle, R.J. J. Clin. Invest. 112, 1186–1191 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chabas, D. et al. Science 294, 1731–1735 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. Yednock, T.A. et al. Nature 356, 63–66 (1992).

    Article  CAS  PubMed  Google Scholar 

  14. Brocke, S., Piercy, C., Steinman, L., Weissman, I.L. & Veromaa, T. Proc. Natl. Acad. Sci. USA 96, 6896–6901 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Miller, D.H. et al. N. Engl. J. Med. 348, 15–23 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. Gordon, E.J., Myers, K.J., Dougherty, J.P., Rosen, H. & Ron, Y. J. Neuroimmunol. 62, 153–160 (1995).

    Article  CAS  PubMed  Google Scholar 

  17. Lovett-Racke, A.E. et al. J. Immunol. 172, 5790–5798 (2004).

    Article  CAS  PubMed  Google Scholar 

  18. Youssef, S. et al. Nature 420, 78–84 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Platten, M., Steinman, L. Multiple sclerosis: trapped in deadly glue. Nat Med 11, 252–253 (2005). https://doi.org/10.1038/nm0305-252

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0305-252

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing