Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

siRNAs knock down hepatitis

This article has been updated

The power of small RNAs to shut down specific gene activities has now been brought to bear on an animal model of hepatitis. Mice infused with an siRNA against a cell death receptor recover liver function after experimentally induced injury (pages 347–351).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: RNAi silencing.

Kimberly Homer

Change history

  • 27 March 2003

    This was incorrect in in print. The request to make the change before a print erratum is published was approved by Linda Miller. Replaced Figure 1 as per the note.

Notes

  1. NOTE: In the version of this article initially published online and in print, Figure 1 was incorrect. The hydroxyl and phosphate groups were incorrectly placed on the siRNA duplexes. This mistake has been corrected in the HTML version. This correction has been appended to the PDF and print versions.

References

  1. Song, E. et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9, 347–351.

  2. Elbashir, S.M., Lendeckel, W. & Tuschl, T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188–200 (2001).

    Article  CAS  Google Scholar 

  3. Plasterk, R.H. RNA silencing: the genome's immune system. Science 296, 1263–1265 (2002).

    Article  CAS  Google Scholar 

  4. Pomerantz, R.J. RNA interference meets HIV-1: will silence be golden? Nat. Med. 8, 659–660 (2002).

    Article  CAS  Google Scholar 

  5. Wajant, H. The Fas signaling pathway: more than a paradigm. Science 296, 1635–1636 (2002).

    Article  CAS  Google Scholar 

  6. Zhang, H. et al. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat. Biotechnol. 18, 862–867 (2000).

    Article  CAS  Google Scholar 

  7. Nakamoto, Y. et al. Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti-Fas ligand antibody therapy. J. Exp. Med. 196, 1105–1111 (2002).

    Article  CAS  Google Scholar 

  8. Ryo, K. et al. Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure. Am. J. Gastroenterol. 95, 2047–2055 (2000).

    Article  CAS  Google Scholar 

  9. Lenardo, M. et al. Mature T lymphocyte apoptosis—immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17, 221–253 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zamore, P., Aronin, N. siRNAs knock down hepatitis. Nat Med 9, 266–267 (2003). https://doi.org/10.1038/nm0303-266

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0303-266

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing