Although past epidemiological studies have supported the theory that there is a genetic component to schizophrenia, the genetic data have been inconsistent. However, an overall analysis indicates several chromosome regions with good candidate genes for schizophrenia susceptibility.
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References
Kendler, K.S. & Diehl, S.R. The genetics of schizophrenia: A current, genetic-epidemiologic perspective. Schizophr. Bull. 19, 261–285 (1993).
Risch, N. Linkage strategies for genetically complex traits. I. Multilocus models. Am. J. Hum. Genet. 46, 222–228 (1990).
Gottesman, I. in Schizophrenia Genesis (W.H. Freeman, New York, 1991).
Riley, B.P. et al. A linkage study of the N-methyl-D-aspartate receptor subunit gene loci and schizophrenia in southern African Bantu-speaking families. Psychiatr. Genet. 7, 57–74 (1997).
Sherrington, R. et al. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 336, 164–167 (1988).
Pulver, A.E. et al. Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am. J. Med. Genet. Neuropsychiatric Genet. 60, 252–260 (1995).
Riley, B.P. & McGuffin, P. Linkage and associated studies of schizophrenia. Sem. Med. Genet. (in press).
Freedman, R. et al. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl. Acad. Sci. USA 94, 587–592 (1997).
Arolt, V. et al. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am. J. Med. Genet. Neuropsychiatric Genet. 67, 564–579 (1996).
Jakob, K. & Beckmann, H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J. Neural Transm. 65, 303–326 (1986).
Murphy, K.C., Jones, L.A. & Owen, M.J. High rates of schizophrenia in adults with velocardial-facial syndrome. Arch. Gen. Psychiatry 56, 940–945 (1999).
Bassett, A.S. & Chow, E.W.C. 22q11 deletion syndrome: A genetic subtype of schizophrenia. Biol. Psychiatry 46, 882–891 (1999).
Mohn, A.R., Gainetdinov, R.R., Caron, M.G. & Koller, B.H. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98, 427–436 (1999).
Kaufmann, C.A. et al. NIMH genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees. Am. J. Med. Genet. Neuropsychiatric Genet. 81, 282–289 (1998).
Riley, B.P. et al. Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in southern African Bantu families. Am. J. Med. Genet. Neuropsychiatric Genet. (in press).
Cox, N.J. et al. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nature Genet. 21, 213–215 (1999).
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Riley, B., Williamson, R. Sane genetics for schizophrenia. Nat Med 6, 253–255 (2000). https://doi.org/10.1038/73085
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DOI: https://doi.org/10.1038/73085
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