On the Market | Published:

Bioluminescent indicators in living mammals

Nature Medicinevolume 4pages245247 (1998) | Download Citation


Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Contag, C., et al. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66, 523–531 (1997).

  2. 2

    Contag, C.H., Contag, P.R., Spilman, S.D., Stevenson, D.K. & Benaron, D.A. Photonic monitoring of infectious disease and gene regulation, in OSA TOPS on Biomedical Optical Spectroscopy and Diagnostics, (eds. Sevick-Muraca, E. & Benaron, D.) 220–224 (Optical Society of America, Washington, DC, 1996).

  3. 3

    Contag, C.H., et al. Photonic detection of bacterial pathogens in a living host. Molec. Micro. 18, 593–603 (1995).

  4. 4

    Thompson, E.M., Adenot, P., Tsuji, F.I. & Renard, J.P. Real-time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. Proc. Natl. Acad. Sci. USA 92, 1317–1321 (1995).

  5. 5

    Hooper, C.E., Ansorge, R.E. & Rushbrooke, J.G. Low-light imaging technology in the life sciences. J. Biolumin. Chemilumin. 9, 113–122 (1994).

  6. 6

    Hooper, C.E., Ansorge, R.E., Browne, H.M. & Tomkins, P. CCD imaging of luciferase gene expression in single mammalian cells. J. Biolumin. Chemilumin. 5, 123–130 (1990).

  7. 7

    White, M.R.H., et al. Real-time analysis of the transcriptional regulation of HIV and hCMV promoters in single mammalian cells, J. Cell Sci. 108, 441–455 (1995).

  8. 8

    Petterson, J., et al. Modulation of virulence factor expression by pathogen target cell contact. Science 273, 1231–1233 (1996).

  9. 9

    Morrey, J.D., Bourn, S.M., Bunch, T.D., Sidwell, R.W. & Rosen, C.A. HIV-1 LTR activation model: Evaluation of various agents in skin of transgenic mice. J. Acquir. Immune Defic. Syndr. 5, 1195–1203 (1992).

  10. 10

    Morrey, j.D., et al. In vivo activation of human immunodeficiency virus type 1 long terminal repeat by UV type A (UV-A) light plus psoralen and UV-B light in the skin of transgenic mice. J. Virol. 65, 5045–5051 (1991).

  11. 11

    Zhang, L., Hellstrom, K.E. & Chen, L. Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo. Clin. Exp. Metastasis 12, 87–92 (1994).

  12. 12

    Hickey, M.J., et al. Luciferase in vivo expression technology: Use of recombinant mycobacterial reporter strains to evaluate antimycobacterial activity in mice. Antimicrob. Agents Chemother. 40, 400–407 (1996).

  13. 13

    Morrey, J.D., Bourn, S.M., Morris, J.L., Bunch, T.D. & Sidwell, R.W. Activation of the human immunodeficiency virus long terminal repeat by abrasion of the skin in transgenic mice. Intervirology 37, 315–320 (1994).

Download references

Author information


  1. Xenogen Corporation, P.O. Box 9497, Stanford, California, 94309-9497, USA

    • Pamela R. Contag
  2. Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California, 94305-5119, USA

    • Pamela R. Contag
    • , I. Nick Olomu
    • , David K. Stevenson
    •  & Christopher H. Contag


  1. Search for Pamela R. Contag in:

  2. Search for I. Nick Olomu in:

  3. Search for David K. Stevenson in:

  4. Search for Christopher H. Contag in:

About this article

Publication history

Issue Date



Further reading