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Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

Nature Medicinevolume 4pages215221 (1998) | Download Citation

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Abstract

The T-cell antigen receptor (TCR) repertoire was studied longitudinally by analyzing the varying lengths of the beta chain CDR3 hypervariable region during the course of HIV-1 infection and following combination antiretroviral therapy. Drastic restrictions in CD8+ T-cell repertoire usage were found at all stages of natural progression and persisted during the first six months of treatment. In contrast, significant CD4+ T-cell repertoire perturbations were not found in early stages of infection but correlated with progression to AIDS. Out of ten patients presenting with pretreatment perturbations, normalization of the CD4+ repertoire was observed in eight good responders, but not in two cases of unsuccessful therapy. These results indicate that, besides CD4+ cell count rise, an efficient control of HIV replication may allow qualitative modifications of the CD4+ repertoire balance.

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Author notes

  1. Guy Gorochov and Avidan U. Neumann: A.U.N. and G.G. contributed equally to this work. Information regarding mathematical analysis should be obtained from A.U.N.; neumann@macs.biu.ac.il

Affiliations

  1. Laboratoire d'Immunologie Cellulaire, CERVI, URA CNRS 625, Hôpital Pitié-Salpétrière, 83 Boulevard de l'Hôpital, 75013, Paris, France

    • Guy Gorochov
    • , Avidan U. Neumann
    • , Anne Kereveur
    • , Christophe Parizot
    • , Taisheng Li
    • , Brigitte Autran
    •  & Patrice Debré
  2. Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel

    • Avidan U. Neumann
  3. Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpétrière, 75013, Paris, France

    • Christine Katlama
  4. Service de Médecine Interne, Hôpital de la Croix Saint-Simon, 75020, Paris, France

    • Marina Karmochkine
    •  & Gilles Raguin

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Correspondence to Guy Gorochov.

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https://doi.org/10.1038/nm0298-215

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