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BMT beats autoimmune disease

Nature Medicinevolume 4pages153155 (1998) | Download Citation


Early clinical trial results show that bone marrow stem cell transplantation for patients with severe autoimmune disease is safe and effective.

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  1. 1

    Burt, R.K., Burns, W. & Hess, A. Bone marrow transplantation for multiple sclerosis. Bone Marrow Transplant. 16, 1–6 (1995).

  2. 2

    Shizuru, J.A., Jerabek, L., Edwards, C.T. & Weissman, I.L. Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment. Biology of Blood and Marrow Transplantation 2, 3–14 (1996).

  3. 3

    Ishida, T. et al. Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. J. Immunol. 152, 3119–3127 (1994).

  4. 4

    Knaan-Shanzer, S., Houben, P., Kinel-Bohre, E.P. & van Bekkum, D.W. Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant. 8, 333–338 (1991).

  5. 5

    Tyndall, A. & Gratwohl, A. Blood and marrow stem cell transplants in autoimmune disease: a consensus report written on behalf of the European league against rheumatism (eular) and the European group for blood and marrow transplantation (ebmt). Bone Marrow Transplant. 19, 643–645 (1997).

  6. 6

    Euler, H.H. et al. Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood 88, 3621–3625 (1997).

  7. 7

    Passweg, J.R. et al. Autologous stem cell transplantation for autoimmune disease. A preliminary report. Blood 90, 233a (1997).

  8. 8

    Fassas, A. et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant. 20, 631–638 (1997).

  9. 9

    Burt, R.K. et al. T-cell depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report of the first three patients. Blood 90, 383a (1997).

  10. 10

    Burt, R.K., Traynor, A. & Ramsey-Goldman, R. Hematopoietic stem-cell transplantation for systemic lupus erythematosus. New England J. Med. 337, 1777–1778 (1997).

  11. 11

    Tyndall, A. et al. Treatment of systemic sclerosis with autologous haemopoietic stem cell transplantation. Lancet 349, 254 (1997).

  12. 12

    Joske, D.J., Ma, D.T., Langlands, D.R. & Owen, E.T. Autologous bone-marrow transplantation for rheumatoid arthritis. Lancet 350, 337–338 (1997).

  13. 13

    Marmont, A.M., van Lint, M.T., Gualandi, F. & Bacigalupo, A. Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. Lupus 6, 545–548 (1997).

  14. 14

    Rooney, C. et al. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 345, 9–13 (1995).

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  1. Texas Children's Cancer Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, 77030, USA

    • Robert Krance
    •  & Malcolm Brenner


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