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BMT beats autoimmune disease

Early clinical trial results show that bone marrow stem cell transplantation for patients with severe autoimmune disease is safe and effective.

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References

  1. Burt, R.K., Burns, W. & Hess, A. Bone marrow transplantation for multiple sclerosis. Bone Marrow Transplant. 16, 1–6 (1995).

    CAS  PubMed  Google Scholar 

  2. Shizuru, J.A., Jerabek, L., Edwards, C.T. & Weissman, I.L. Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment. Biology of Blood and Marrow Transplantation 2, 3–14 (1996).

    CAS  PubMed  Google Scholar 

  3. Ishida, T. et al. Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. J. Immunol. 152, 3119–3127 (1994).

    CAS  PubMed  Google Scholar 

  4. Knaan-Shanzer, S., Houben, P., Kinel-Bohre, E.P. & van Bekkum, D.W. Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant. 8, 333–338 (1991).

    CAS  PubMed  Google Scholar 

  5. Tyndall, A. & Gratwohl, A. Blood and marrow stem cell transplants in autoimmune disease: a consensus report written on behalf of the European league against rheumatism (eular) and the European group for blood and marrow transplantation (ebmt). Bone Marrow Transplant. 19, 643–645 (1997).

    Article  CAS  Google Scholar 

  6. Euler, H.H. et al. Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood 88, 3621–3625 (1997).

    Google Scholar 

  7. Passweg, J.R. et al. Autologous stem cell transplantation for autoimmune disease. A preliminary report. Blood 90, 233a (1997).

    Google Scholar 

  8. Fassas, A. et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant. 20, 631–638 (1997).

    Article  CAS  Google Scholar 

  9. Burt, R.K. et al. T-cell depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report of the first three patients. Blood 90, 383a (1997).

    Google Scholar 

  10. Burt, R.K., Traynor, A. & Ramsey-Goldman, R. Hematopoietic stem-cell transplantation for systemic lupus erythematosus. New England J. Med. 337, 1777–1778 (1997).

    Article  CAS  Google Scholar 

  11. Tyndall, A. et al. Treatment of systemic sclerosis with autologous haemopoietic stem cell transplantation. Lancet 349, 254 (1997).

    Article  CAS  Google Scholar 

  12. Joske, D.J., Ma, D.T., Langlands, D.R. & Owen, E.T. Autologous bone-marrow transplantation for rheumatoid arthritis. Lancet 350, 337–338 (1997).

    Article  CAS  Google Scholar 

  13. Marmont, A.M., van Lint, M.T., Gualandi, F. & Bacigalupo, A. Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. Lupus 6, 545–548 (1997).

    Article  CAS  Google Scholar 

  14. Rooney, C. et al. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 345, 9–13 (1995).

    Article  CAS  Google Scholar 

Download references

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Krance, R., Brenner, M. BMT beats autoimmune disease. Nat Med 4, 153–155 (1998). https://doi.org/10.1038/nm0298-153

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