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DNA vaccination exploits normal biology

Nature Medicinevolume 4pages147148 (1998) | Download Citation

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A live vaccine strain of salmonella can itself be used as a highly effective vehicle for oral delivery of DNA vaccines.

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    Sizemore, D.R., Branstrom, A.A. & Sadoff, J.C. Attenuated bacteria as a DNA delivery vehicle for DNA-mediated immunization. Vaccine 15, 804–807 (1997).

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    Hackett, J. Use of Salmonella for heterologous gene expression and vaccine delivery systems. Curr. Opin. Biotechnol. 4, 611–615 (1993).

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    Gould-Fogerite, S. Delivery of genetic information by DNA cochleates. In IBC's 3rd Annual Conference on Genetic Vaccines and Immunotherapeutic Strategies (ed. Thibeault, C.A.). In press (International Business Communications Inc., Orlando, 1997).

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    Jones, D.H., Corris, S., McDonald, S., Clegg, J.C.S. & Farrar, G.H. Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine 15, 814–817 (1997).

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Affiliations

  1. National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, U.K.

    • Douglas B. Lowrie

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https://doi.org/10.1038/nm0298-147

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