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Therapeutic replication-competent herpes virus

Nature Medicinevolume 4page133 (1998) | Download Citation


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    Martuza, R.L. Act locally, think globally. Nature Med. 12, 1323 (1997).

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    Maclean, A.R. et al. Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence related sequences in Glasgow strain 17+ between immediate eariy gene 1 and the ‘a’ sequence. J. Gen. Virol. 72,631–639 (1991).

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    Kesari, S. et al. A mutant herpes simplex virus replicates in brain tumours but not in neurons derived from a human embryonal carcinoma cell line. Lab. Invest. 73, 636-648 (1995).

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Author notes

    • G. Cruickshank

    Present address: University Dept. Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK


  1. Glasgow University Dept. of Clinical Oncology, Beatson Oncology Centre, Glasgow, G116NT, UK

    • R. Rampling
  2. Glasgow University Dept. of Neurosurgery, Southern General Hospital, Glasgow, G514TF, UK

    • G. Cruickshank
  3. Glasgow University Division of virology, Institute of Virology, Glasgow, G11 5JR, UK

    • A. Maclean
  4. Neurovirology Research Laboratories, Institute of Neurological Science, Glasgow, G51 4TF, UK

    • M. Brown


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