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References
Martuza, R.L. Act locally, think globally. Nature Med. 12, 1323 (1997).
Maclean, A.R. et al. Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence related sequences in Glasgow strain 17+ between immediate eariy gene 1 and the ‘a’ sequence. J. Gen. Virol. 72,631–639 (1991).
Kesari, S. et al. A mutant herpes simplex virus replicates in brain tumours but not in neurons derived from a human embryonal carcinoma cell line. Lab. Invest. 73, 636-648 (1995).
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Rampling, R., Cruickshank, G., Maclean, A. et al. Therapeutic replication-competent herpes virus. Nat Med 4, 133 (1998). https://doi.org/10.1038/nm0298-133c
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DOI: https://doi.org/10.1038/nm0298-133c
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