News & Views | Published:

A lesson from the HIV patient: The immune response is still the bane (or promise) of gene therapy

Nature Medicine volume 2, pages 165167 (1996) | Download Citation

Subjects

The disappearance of genetically modified CTLs following infusion into AIDS patients led to a surprising observation: What are the implications for active immunotherapy (pages 216–223)?

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Gene therapy for cystic fibrosis: Challenges and future directions. J. Clin. Invest. 96, 2547–2554 (1995).

  2. 2.

    , , , & Recent advances in the application of gene therapy to human disease. Am. J. Med. 99, 537–552 (1995).

  3. 3.

    et al. Reconstitution of cellular immunity against CMV in recipients of allogeneic bone marrow by adoptive transfer of T cell clones from the donor. N. Engl. J. Med. 333, 1038–1044 (1995).

  4. 4.

    et al. Rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med. 2, 216–223 (1996).

  5. 5.

    et al. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nature Med. 1, 1017–1023 (1995).

  6. 6.

    , , & Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004–2015 (1995).

  7. 7.

    , & Progress toward gene therapy for HIV infection. Gene Ther. 1, 13–26 (1995).

  8. 8.

    et al. Ribozymes as potential anti-HIV-1 therapeutic agents. Science 247, 1222–1225 (1990).

  9. 9.

    et al. Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytres armed with universal T cell receptors. Blood 84, 2878–2889 (1994).

  10. 10.

    et al. Vaccine therapy using recombinant gp160 in early HIV infection. AIDS Res. Hum. Retrovir. 8, 1333 (1992).

  11. 11.

    New small molecule immunosup-pressants for transplantation: Review of essential concepts. J. Heart Lung Transplant. 12, S275–S286 (1993).

  12. 12.

    & , Costimulatory Pathway Blockade. in Recent Developments in Transplantation Medicine: Adhesion Molecules, Fusion Proteins, Novel Peptides, and Monoclonal Antibodies (eds Salomon, D.R. & Sollinger, H.) 139–160 (Physicians and Scientists Publ. Co., Glenview, Illinois, 1995).

  13. 13.

    et al. T10B9. 1A-31 Anti-human a-b T cell receptor antibody. in Recent Developments in Transplantation Medicine: Adhesion Molecules, Fusion Proteins, Novel Peptides, and Monoclonal Antibodies (eds Salomon, D.R. & Sollinger, H.) 139–160 (Physicians and Scientists Publ. Co., Glenview, Illinois, 1995).

  14. 14.

    Relevant targets for therapy with monoclonal antibodies in allograft transplantation. Kidney Int. 46, 540–553 (1994).

  15. 15.

    , , , & . Combined Anti-CD2 and Anti-CD3 receptor monoclonal antibodies induce donorspecific tolerance in a cardiac transplant model. J. Immunol. 151, 7249–7259 (1993).

  16. 16.

    et al. An anti-CD2 monoclonal antibody that elicits alloantigen-specific hypore-sponsiveness. in Cybercongress: Transplantation in the Next Millennium. Advances in Technology and Immunosuppression (November 13–15, 1995 (abs.).

  17. 17.

    et al. Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nature Med. 1, 330–336 (1995).

  18. 18.

    et al. High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxicT lymphocyte frequencies in patients with HTLV-1-associated neurological disease. J. Exp. Med. 177, 1567–1573 (1993).

Download references

Author information

Affiliations

  1. Medlmnune, Inc., 35 W. Watkins Mill Road, Gaithersburg, Maryland 20878, USA

    • Scott Koenig

Authors

  1. Search for Scott Koenig in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm0296-165

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing