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Of telomeres and tumors

Nature Medicinevolume 2pages158159 (1996) | Download Citation


The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.

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  1. 1

    deLange, T. Telomere dynamics and genome instability. in Telomeres (eds Blackburn, E.H. & Greider, C.W.) 265–293 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1995).

  2. 2

    Counter C.M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921–1929 (1992).

  3. 3

    Harley, C.B., Futcher, A.B. & Greider, C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458–460 (1990).

  4. 4

    Blasco, M.A., Rizen, M., Greider, C.W. & Hanahan, D. Differential regulation of telomerase activity and telomerase RNA during multistage tumorigenesis. Nature Genet. 12, 1–5 (1996).

  5. 5

    Chong, L. et al. A human telomeric protein. Science 270, 1663–1667 (1995).

  6. 6

    Harley, C.B. Telomeres and aging. in Telomeres (eds Blackburn, E. H. & Greider, C.W.) 247–263 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1995).

  7. 7

    Kim, N.W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011–2014 (1994).

  8. 8

    Feng, J. et al. The RNA component of human telomerase. Science 269, 1236–1241 (1995).

  9. 9

    Counter, C.M., Hirte, H.W., Bacchetti, S. & Harley, C.B. Telomerase activity inhuman ovarian carcinoma. Proc. Natl. Acad. Sci. USA 91, 2900–2904 (1994).

  10. 10

    Hiyama, E. et al. Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Med. 1, 249–255 (1995).

  11. 11

    Blasco, M., Funk, W.B. & Greider, C.W. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267–1270 (1995).

  12. 12

    Broccoli, D., Young, J. & deLange, T. . Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92, 9082–9086 (1995).

  13. 13

    Lundblad, V. & Blackburn, E.H. An alternative pathway for yeast telomere maintenance rescues est1 senescence. Cell 73, 347–360 (1993).

  14. 14

    Biessmann, H. et al. HeT-A, a transposable element specifically involved in “healing” broken chromosome ends in Drosophila. Mol. Cell. Biol. 12, 3910–3918 (1992).

  15. 15

    Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. & Reddel, R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240–4248 (1995).

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  1. an assistant editor of Nature Medicine

    • Nancy Axelrod


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